Repeated dosages of opioids can quickly lead to tolerance and physical dependence. Symptoms can include: extreme anxiety, nausea or vomiting, muscle aches, a runny nose, sneezing, diarrhea, sweating and fever. The symptoms of opioid withdrawal may develop within minutes or up to several days following reduction or stopping. However, the severity and duration of withdrawal depend on the type and dose of opioid taken and the duration and frequency of use. Withdrawal from any opioid produces similar signs and symptoms. Opioid withdrawal can be helped by the use of opioid replacement therapy, and symptoms may be relieved by the use of medications including lofexidine and clonidine. When withdrawal symptoms are due to recreational opioid use, the term opioid use disorder is used, whereas when due to prescribed medications, the term prescription opioid use disorder is used. All opioids, both recreational drugs and medications, when reduced or stopped, can lead to opioid withdrawal symptoms. Signs and symptoms of withdrawal can include drug craving, anxiety, restless legs, nausea, vomiting, diarrhea, sweating, and an increased heart rate. Opioid use triggers a rapid adaptation in cellular signalling pathways that means, when rapidly withdrawn, there can be adverse physiological effects. Opioid withdrawal is a set of symptoms (a syndrome) arising from the sudden withdrawal or reduction of opioids where previous usage has been heavy and prolonged. Withdrawal symptoms of opiates Suboxone tablet ( Buprenorphine/ naloxone) delivers the opioid drug through a sublingual route, giving fast onset of effects.
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